Parkinson’s disease (PD) is known to be a neurological disorder caused by the degeneration of nerve cells due to the aggregation of a misfolded protein called alpha-synuclein (AS) in the hippocampal region of the brain. The existent theory of the disease suggests that alpha-synuclein aggregation causes the loss of motor functions in PD patients. However, very little is known about the initiation of this protein aggregation.

Aggregation of alpha-synuclein leads to Parkinson’s disease

A recent report published in Scientific Reports (a journal of NPG) suggests that a gut bacteria might be behind the initiation of protein aggregation in PD. The study conducted in two models – rats and nematodes (C. elegans) – reveal intriguing results. Results show that these organisms showed increased deposition of misfolded AS in the gut and the brain when exposed to E. coli (a gut microbe) producing the protein curli when compared to the unexposed organisms. The exposed organisms also showed immune response to the bacterial protein was identical to that found in PD towards AS. These results suggest that the bacterial protein curli must be the triggering agent that initiates AS aggregation by converting the curli protein aggregates into AS aggregates, a phenomenon called cross-seeding. This is also supported by the fact that PD patients develop digestive problems including constipation and anosmia up to 20 years before diagnosis in PD, possibly due to the aggregation of AS through curli as shown by the recent study.

p.s: Detailed version of the article coming soon …

http://www.geneticengg.com/wp-content/uploads/2017/01/prakinsons.jpghttp://www.geneticengg.com/wp-content/uploads/2017/01/prakinsons-150x150.jpgJoel JosephGeneticsHealth and Medicinealpha-synuclein,e.coli,gut microbe,Parkinson's diseaseParkinson’s disease (PD) is known to be a neurological disorder caused by the degeneration of nerve cells due to the aggregation of a misfolded protein called alpha-synuclein (AS) in the hippocampal region of the brain. The existent theory of the disease suggests that alpha-synuclein aggregation causes the loss of...When Nature and Science meet, Magic happens !